She is known as "The First Lady of Football". Her appointment with Birmingham City began in March 1993, when she was 23. In 2002 she became the first woman to hold such a post in the top flight of English football when the team was promoted. She oversaw the company's flotation in 1997, thus becoming the youngest managing director of a UK plc. She left in 2009 when her employers David Sullivan and David Gold sold the club for £81.5 million. In January 2010 she was appointed vice-chairman of West Ham United following Sullivan and Gold's purchasing of the club.
Baroness Brady is a regular writer for the Woman & Home magazine and The Sun. She has also published four books including two novels.
On 22 September 2014, Karren Brady was elevated to the House of Lords as a Conservative life peer, taking the title Baroness Brady.